Effects of physical exercise on neuro-immune function of rats with chronic fatigue syndrome

Objective To probe into the neuro-immune mechanism of chronic fatigue syndrome and the intervention effects of physical exercise.Methods Forty male SD rats were randomly divided into 4 groups:control group,model group,exercise model group and exercise group.The rat model of chronic fatigue syndrome was made by sleep deprivation and overload exhaustive swimming.Exercise model was made with 8-week spontaneous wheel running.The concentration of 5-hydroxytryptamine(5-HT) in hippocampus and occipital cortex was measured with high performance liquid chromatography.ELISA was employed to measure levels of interferon-γ(IFN-γ) and interleukine-4(IL-4) in serum,and the ratio of IFN-γ/IL-4.Results Compared with the control group,the concentration of 5-HT,the level of IFN-γ and the ratio of IFN-γ/IL-4 were significantly decreased in model group(P0.01).Compared with the model group,rats in exercise model group had higher levels of 5-HT,IFN-γ and a higher ratio of IFN-γ/IL-4(P0.05).The concertration of 5-HT was significantly increased in the exercise group than that of in the control group(P0.05).Conclusion As an effective protection measure,long-term exercise can lower neuroimmunity injury caused by chronic fatigue syndrome.