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EFFECTS OF PHYSICAL EXERCISE ON CONCENTRATION OF 5-HT IN DIFFERENT CEREBRAL TISSUES OF RATS UNDER CHRONIC FATIGUE SYNDROME

Zhao Ya

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Abstract

[Objective] To probe into the neuro-mechanism of chronic fatigue syndrome and the intervention effects of physical exercise.[Methods] 40 male SD rats were randomly divided into 4 groups:control group,model group,exercise model group and exercise group.The rat model of chronic fatigue syndrome was made by sleep deprivation plus overload exhaustive swimming.Exercise mode was 8-week spontaneous wheel running.The concentrations of 5-HT in hippocampus and occipital cortex were measured by high performance liquid chromatography.[Results] Compared with control group,the concentration of 5-HT was significantly decreased in model group(P﹤0.01).Compared with model group,exercise model group got higher level of 5-HT(P﹤0.05).The concentration of 5-HT was significantly increased in exercise group than that in control group(P﹤0.05).[Conclusion] As an effective protection measure,long-term exercise can lower neuro-injury caused by chronic fatigue syndrome.

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What this paper is about

[Objective] To probe into the neuro-mechanism of chronic fatigue syndrome and the intervention effects of physical exercise.[Methods] 40 male SD rats were randomly divided into 4 groups:control group,model group,exercise model group and exercise group.The rat model of chronic fatigue syndrome was made by sleep deprivation plus overload exhaustive swimming.Exercise mode was 8-week spontaneous wheel running.The concentrations of 5-HT in hippocampus and occipital cortex were measured by high performance liquid chromatography.[Results] Compared with control group,the concentration of 5-HT was significantly decreased in model group(P﹤0.01).Compared with model group,exercise model group got higher level of 5-HT(P﹤0.05).The concentration of 5-HT was significantly increased in exercise group than that in control group(P﹤0.05).[Conclusion] As an effective protection measure,long-term exercise can lower neuro-injury caused by chronic fatigue syndrome.

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Available abstract

[Objective] To probe into the neuro-mechanism of chronic fatigue syndrome and the intervention effects of physical exercise.[Methods] 40 male SD rats were randomly divided into 4 groups:control group,model group,exercise model group and exercise group.The rat model of chronic fatigue syndrome was made by sleep deprivation plus overload exhaustive swimming.Exercise mode was 8-week spontaneous wheel running.The concentrations of 5-HT in hippocampus and occipital cortex were measured by high performance liquid chromatography.[Results] Compared with control group,the concentration of 5-HT was significantly decreased in model group(P﹤0.01).Compared with model group,exercise model group got higher level of 5-HT(P﹤0.05).The concentration of 5-HT was significantly increased in exercise group than that in control group(P﹤0.05).[Conclusion] As an effective protection measure,long-term exercise can lower neuro-injury caused by chronic fatigue syndrome.

Key concepts: Chronic fatigue syndrome, Medicine, Hippocampus, Chronic fatigue, Internal medicine, Rat model, Animal model, Physical exercise

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EFFECTS OF PHYSICAL EXERCISE ON CONCENTRATION OF 5-HT IN DIFFERENT CEREBRAL TISSUES OF RATS UNDER CHRONIC FATIGUE SYNDROME — Research Paper | ScholarLens