Effects of levofloxacin combined with piperacillin/tazobactam on treatment of ventilator-associated pneumonia

OBJECTIVE To evaluate the efficacy and safety of levofloxacin combined with piperacillin/tazobactam on the patients with ventilator-associated pneumonia(VAP).METHODS The clinical effect of Levofloxacin combined with piperacillin/tazobactam on ventilator-associated pneumonia in 98 paitiens with VAP were retrospectively analyzed.RESULTS Totally 46 patients(46.9%) were cured,28 patients(28.6%) were markablely improved,and 24 patients(24.5%) were ineffective.The total clinical efficacy rate was 75.5%.89 strains of bacteria were isolated,and Gram-negative bacilli were the dominant pathogens(77.5%).The bacterial clearance rate was 76.4%.The prevalence of adverse reaction was 5.1%,in which 3 cases had clinical significance(rash,dyspnea,injection site pain and diarrhea,respectively) and 2 cases had abnormal laboratory findings(hepatic dysfuction,eosinophilia and so on).All events were mild and transient.CONCLUSION Levofloxacin combined with piperacillin/tazobactam is effective and safe for patients with VAP.