The applied value of quantitative tissue Doppler imaging on assessing left ventricular function in patients with early stage type 2 diabetes

Objective To investigate the application of tissue Doppler imaging(TDI) in assessing left ventricular function of patients with early phase type 2 diabetes(T2DM).Methods Forty-five early stage type 2 diabetes patients(T2DM group) and forty-five normal subjects(NC group) were enrolled in this study.In all individuals,the ventricular mural motion spectrum in the side of left ventricle of mitral valve ring was detected through TDI,and the motion peak velocity of systole,early diastole and late diastole(Vs,Ve,Va) was measured,and the ratio of Ve/Va was calculated;the flow spectrum of mitral orifice was detected through pulse Doppler(PDE),and the flow velocity of early diastole and late diastole(E,A) and the ratio of E/A were calculated;the left ventricular ejection fraction(LVEF) was detected by Simpson′s method through conventional echocardiography.Results Systolic function parameters showed that the LVEF values of both T2DM group and NC group were all in normal range,and the values had no significant difference(P0.05),while the Vs was lower in T2DM group than that in NC group(P0.05).Diastolic function parameters demonstrated that the Ve,Ve/Va,E/A in T2DM group were lower than those in NC group(all P0.05),while Va and A were higher in T2DM group than those in NC group(all P0.05).The detectable rate of abnormality of diastolic function by TDI was higher than that by PDE(51.1% vs 26.7%,P0.01).Conclusions The abnormalities of diastolic and systolic function exist already in early stage T2DM patients,and the measurement of the mitral annular motion velocity through TDI may provide a new and more sensitive quantitative index to assess the left ventricular function.