Significance of Prealbumin,Retinol Binding Protein and Total Bile Acid on Hepatic Cirrhosis Classification

Objective:To investigate the role of prealbumin(PA),retinol binding protein(RBP) and total bile acid(TBA) in Child-Pugh classification of hepatic cirrhosis.Methods:One hundred and twenty patients with hepatic cirrhosis were enrolled and divided into three groups according to Child-Pugh standard,A group(A grade,40 cases),B group(B grade,42 cases) and C group(C grade,38 cases),respectively.And 40 healthy cases were as normal control.Automatic biochemistry analysator was used to assay serum PA,RBP and TBA.Results:The levels of PA and RBP were significantly lower in patients with hepatic cirrhosis than those in normal control(P 0.01 or P 0.05),and decreased gradually with the elevation of Child-Pugh classification,which was significantly different between three groups(P 0.01 or P 0.05).However,the level of TBA was significantly higher in patients with hepatic cirrhosis than that in normal control group(P 0.01 or P 0.05),and elevated gradually with the increase in Child-Pugh classification.There was also a significant difference between three groups(P 0.01 or P 0.05).Conclusion:There was a clinical significance in PA,RBP and TBA to evaluate the classification and prognosis in patients with hepatic cirrhosis.