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UPLC determination of content and entrapment efficiency of elemene liposomes

Xie Tian

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Abstract

Objective:To develop an UPLC method for determination of content and entrapment efficiency of elemene liposomes.Methods:The analytes was separated on a XR-ODSⅡ(2.2 μm,75 mm×3.0 mm)column with acetonitrile-water(80∶20)as the mobile phase at a flow rate of 1.0 mL·min-1.The column temperature was 40 ℃ and detection wavelength was set at 210 nm. Results:Elemene had a good linear relation in a range of 1-100 μg·mL-1.The average entrapment efficiency of elemene liposomes reached(99.8±0.4)%.Conclusion: UPLC method for determination of content and entrapment efficiency of elemene liposomes was simple, fast and accurate.

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What this paper is about

Objective:To develop an UPLC method for determination of content and entrapment efficiency of elemene liposomes.Methods:The analytes was separated on a XR-ODSⅡ(2.2 μm,75 mm×3.0 mm)column with acetonitrile-water(80∶20)as the mobile phase at a flow rate of 1.0 mL·min-1.The column temperature was 40 ℃ and detection wavelength was set at 210 nm. Results:Elemene had a good linear relation in a range of 1-100 μg·mL-1.The average entrapment efficiency of elemene liposomes reached(99.8±0.4)%.Conclusion: UPLC method for determination of content and entrapment efficiency of elemene liposomes was simple, fast and accurate.

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Available abstract

Objective:To develop an UPLC method for determination of content and entrapment efficiency of elemene liposomes.Methods:The analytes was separated on a XR-ODSⅡ(2.2 μm,75 mm×3.0 mm)column with acetonitrile-water(80∶20)as the mobile phase at a flow rate of 1.0 mL·min-1.The column temperature was 40 ℃ and detection wavelength was set at 210 nm. Results:Elemene had a good linear relation in a range of 1-100 μg·mL-1.The average entrapment efficiency of elemene liposomes reached(99.8±0.4)%.Conclusion: UPLC method for determination of content and entrapment efficiency of elemene liposomes was simple, fast and accurate.

Key concepts: Chemistry, Chromatography, Liposome, Entrapment, High-performance liquid chromatography, Analyte, Linear range, Acetonitrile

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