Effect of breviscapine on learning memory ability and the expression of β-amyloid protein of brain tissue in natural aging mice

OBJECTIVE To study the the cerebral protection of breviscapine for natural aging mice by measuring learning and memory ability and some biochemical indexes in brain tissue.METHODS Natural aging male KM mice were randomly divided into 5 groups: Control group;L-Bre group(0.06 g· kg-1);M-Bre group(0.12 g·kg-1);H-Bre group(0.24 g·kg-1) and Nim group(0.03 g·kg-1).All the mice were administrated by ig with drugs or water in the same volume for 30 days.The Morris water maze was used to observe the learning and memory ability of model mice.Biochemical methods were used to determine the activity of SOD and AchE and the content of MDA and β-amyloid protein in brain tissue.RESULTS(1) Breviscapine could significantly improve the memory of natural aging mice;(2) Compared with the control group,breviscapine could increase the activities of SOD and decrease the content of MDA and β-amyloid protein in the brain tissue;(3) Breviscapine could also significantly decrease the activity of AchE in the brain tissue.CONCLUSION Breviscapine could improve the ability of learning and memory of natural aging mice,and its mechanism might involve in increasing the activities of SOD,reducing the level of MDA and β-amyloid protein,decreasing the activity of AchE in brain tissue.