2007•Journal of ToxicologyRequires access

Changes of GABA and its catabolic enzymes in the visual cortex of morphine-dependent rats

Yanfei Li

Abstract

Objective To investigate the changes of γ-aminobutyric acid(GABA) content and glutamic acid decarboxylase(GAD),γ-aminobutyric acid transaminase(GABA-T) activity in visual cortex of morphine-dependent rats.Methods Paper electrophoresis was employed to detect GABA content in visual cortex and spectrophotometric method was used to investigate the activity of GAD and GABA-T in each experimental group.Results GABA content in visual cortex of rats decapitated before the last morphine injection was significantly decreased(0.09±0.03)μmol/mg compared with saline control(0.17±0.05)μmol/mg.GABA content of rats decapitated after the last morphine injection restored to normal level.Conclusion Visual cortex is in disinhibition with chronic morphine exposure.

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Key concepts: Visual cortex, Disinhibition, Morphine, Glutamate decarboxylase, Cortex (anatomy), Endocrinology, Internal medicine, Aminobutyric acid