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Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat.

Misao Honda, Masanori Inoue, Yoichi Okada, Masato Yamamoto

Open publisher page 21 citations

Abstract

Diabetes mellitus (DM) often causes neural dysfunctions, including visual disorders. To investigate the effect of hyperglycemia on the visual system, we studied the metabolism of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter that has an important role in visual functions. We determined the GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) in streptozotocin (STZ)-induced DM rats. The GABA content and activities of GAD and GABA-T were decreased in the retinas of STZ-treated rats. The GABA content and GAD activity were reduced in the SC of STZ-treated rats, whereas GABA-T activity showed no marked change. This GABA reduction in the diabetes may be correlated with visual dysfunctions.

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What this paper is about

Diabetes mellitus (DM) often causes neural dysfunctions, including visual disorders. To investigate the effect of hyperglycemia on the visual system, we studied the metabolism of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter that has an important role in visual functions. We determined the GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) in streptozotocin (STZ)-induced DM rats. The GABA content and activities of GAD and GABA-T were decreased in the retinas of STZ-treated rats. The GABA content and GAD activity were reduced in the SC of STZ-treated rats, whereas GABA-T activity showed no marked change. This GABA reduction in the diabetes may be correlated with visual dysfunctions.

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Available abstract

Diabetes mellitus (DM) often causes neural dysfunctions, including visual disorders. To investigate the effect of hyperglycemia on the visual system, we studied the metabolism of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter that has an important role in visual functions. We determined the GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) in streptozotocin (STZ)-induced DM rats. The GABA content and activities of GAD and GABA-T were decreased in the retinas of STZ-treated rats. The GABA content and GAD activity were reduced in the SC of STZ-treated rats, whereas GABA-T activity showed no marked change. This GABA reduction in the diabetes may be correlated with visual dysfunctions.

Key concepts: Glutamate decarboxylase, GABAergic, Superior colliculus, Streptozotocin, Internal medicine, Endocrinology, GABA transaminase, Retina

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Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat. — Research Paper | ScholarLens