Influence study of glucose fluctuation on prognosis of acute cerebral infarction after thrombolytic therapy

Objective To explore the influence of glucose fluctuation on prognosis of acute cerebral infarction after thrombolytic therapy. Methods 66 patients with acute cerebral infarction admitted to our hospital from June 2012 to June 2014 were selected,according to mean amplitude of glycemic excursions(MAGE),patients were divided into high MAGE group and low MAGE group,and were taken with urokinase for thrombolytic.Continuous blood glucose was tested by continuous glucose monitoring system.Indexes of continuous blood glucose including 24 h mean blood glucose(24MBG),percentage of time of blood glucose less than 3.9 mmol/L in a day(PT3.9),and percentage of time of blood glucose more than 7.8 mmol/L in a day(PT7.8) was compared between the two groups.The incidence of adverse reaction within 90 days treatment and difference of Rankin score was also compared between both groups. Results There was no statistical difference in PT3.9between the two groups(P0.05).In the high MAGE group,24 MBG,PT7.8,incidence of adverse reaction,and Rankin score was(8.4±2.4) mmol/L,(33.8±10.7)%,21.2%,and(3.3±0.9) points in turn,was higher than that in the low MAGE group(P0.05). Conclusion The prognosis in patient with acute cerebral infarction with large amplitude of glucose fluctuation after thrombolytic therapy is poor.Controlling blood glucose and decreasing glucose fluctuation amplitude are beneficial to improve the thrombolytic effect and prognosis.