The Influence of Blood Glucose on the Reperfusion and Prognosis of Intravenous Thrombolysis Therapy in Patients with Acute Cerebral Infarction

Objective To observe random blood glucose increase on the reperfusion and prognosis of intravenous thrombolysis therapy in patients with acute cerebral infarction.Methods The 78 patients with acute cerebral infarction treated by intravenous thrombolysis therapy were randomly divided into normal glucose group(Glu7.8 mmol/L)and high blood glucose group(Glu≥7.8 mmol/L) so as to observe the thrombolysis effects(the changes of MRI ischemic penumbra and scoring of neurological deficit(NIHSS) before and after the treatment) and short-term prognosis according to the first random blood glucose as inpatients.Results The success rate of thrombolysis in the two groups had no significant difference;MRI ischemic penumbra improvement and neurological deficits(NIHSS) scoring of the normal glucose group were better than those of the high blood glucose group.And the high blood glucose group had more cerebrovascular events than the normal glucose group(the bleeding of reperfusion).Conclusion The ischemic penumbra after reperfusion was poor in patients with acute cerebral infarction treated by intravenous thrombolysis therapy in case of random high blood glucose,which increases and aggravates cerebrovascular events,resulting in poor short-term prognosis.