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The Relationship between the Intrahepatic Cholestasis of Pregnancy and the Fetal Growth Retardation

Wen Sheng-shu

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Abstract

Objective: To study the relationship between the intrahepatic cholestasis of pregnancy(ICP) and the fetal growth retardation(FGR).Methods: A respectively method was applied to analyse the weight of new-born serum bilirubin,and liver function in 122 patients with ICP and another 122 normal pregnant women as controls,and to demonstrate the relationship between the weight of new-born and serum bilirubin or liver function.Results: The occurrence of preterm birth,mecomium in amnion,and neonatal Apgar scores were lower in ICP group than those in controls.The mean weight of new-born was 3233.9±1475.5 g in ICP group and the prevalence of FGR was 3.3% which was similar to control group.These was no relationship between the weight of new-born and serum bilirubin and liver function by multi-factor lineal analysis.Conclusions: There is no adverse effect of ICP on the fetal growth.

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Objective: To study the relationship between the intrahepatic cholestasis of pregnancy(ICP) and the fetal growth retardation(FGR).Methods: A respectively method was applied to analyse the weight of new-born serum bilirubin,and liver function in 122 patients with ICP and another 122 normal pregnant women as controls,and to demonstrate the relationship between the weight of new-born and serum bilirubin or liver function.Results: The occurrence of preterm birth,mecomium in amnion,and neonatal Apgar scores were lower in ICP group than those in controls.The mean weight of new-born was 3233.9±1475.5 g in ICP group and the prevalence of FGR was 3.3% which was similar to control group.These was no relationship between the weight of new-born and serum bilirubin and liver function by multi-factor lineal analysis.Conclusions: There is no adverse effect of ICP on the fetal growth.

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Available abstract

Objective: To study the relationship between the intrahepatic cholestasis of pregnancy(ICP) and the fetal growth retardation(FGR).Methods: A respectively method was applied to analyse the weight of new-born serum bilirubin,and liver function in 122 patients with ICP and another 122 normal pregnant women as controls,and to demonstrate the relationship between the weight of new-born and serum bilirubin or liver function.Results: The occurrence of preterm birth,mecomium in amnion,and neonatal Apgar scores were lower in ICP group than those in controls.The mean weight of new-born was 3233.9±1475.5 g in ICP group and the prevalence of FGR was 3.3% which was similar to control group.These was no relationship between the weight of new-born and serum bilirubin and liver function by multi-factor lineal analysis.Conclusions: There is no adverse effect of ICP on the fetal growth.

Key concepts: Medicine, Cholestasis of pregnancy, Cholestasis, Birth weight, Growth retardation, Fetus, Fetal growth, Internal medicine

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