Relationship between severe intrahepatic cholestasis of pregnancy and petal growth retardation

Objective To study the relationship between severe intrahepatic cholestasis of pregnancy(ICP) and fetal growth retardation(FGR).Methods The data of 48 patients with severe ICP and the other 48 normal pregnant women as controls were retrospectively analysed.The weight of newborns,serum bilirubin,and liver function were comparatively studied to demonstrate the relationship between the weight of newborns and serum bilirubin or liver function. Results The occurrence of preterm birth,meconium in amnion,and neonatal Apgar score were lower in ICP group than controls.The mean weight of newborns was 3029.1±1042.5g in ICP group and the prevalence of FGR was 6.3% which was similar to controls.There was no relationship between the weight of newborns and serum bilirubin and liver function by multi-factor linear analysis.Conclusion There is no adverse effect of ICP on the fetal growth.