Effect of "Tang Shen Ning" on the Expression of ET,CGRP in Blood of Diabetic Nephropathy Rats

Objective To study the effect of Tang Shen Ning on the expression of transforming endothelin(ET),calcitonin gene related peptide(CGRP)and CGRP/ET in renal tissue of diabetic rat.Methods Adopting the methods of repetitious intraperitoneal injections with little dosage of streptozotocin(STZ) to build the model of diabetic rat.Dividing the rat randomly into normal group,diabetic model group,Tang Shen Ning therapy group,Tang Shen Ning +RI therapy group,RI therapy group and Fosinopril group.After 8 weeks' observation,the level of blood glucose was measured by biochemistry,24hU-Alb,ET,CGRP in blood of the rat.were measured by radioimmunity.Results The blood glucose,24hU-Alb,in diabetic model group are all obviously higher than those in normal group,CGRP and ET are higher than the normal group,and the CGRP/ET are obvious higher.After 8 weeks' observation,the level of 24h U-Alb,the CGRP/ET of Tang Shen Ning therapy group are obvious declined(P0.01 or P0.05).Conclusions Tang Shen Ning can improve the hemodynamics of diabetic rat,and lower albuminuria.