2009•Chinese Journal of Laboratory DiagnosisRequires access
The Influences of insulin-like growth factor-I and Simvastatin on the proliferation of human lung fibroblast
Sun Wen
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Abstract
Objective Study on the influences of Simvastatin and IGF-1 on the proliferation of human lung fibroblast.Methods human lung fibroblast was cultured and MTT colorimetry assay was used to determine the proliferation of human lung fibroblast,the influences of IGF-1 and Simvastatin on the proliferation of human lung fibroblast was observed in vitro.Results The proliferation of human lung fibroblast was inhibited by Simvastatin.Combination of IGF-1 and Simvastatin can inhibit the proliferative capability of human lung fibroblast.Conclusion Simvastatin potently inhibited while IGF-I stimulate human lung fibroblast proliferation.