Effects of puerarin on blood coagulation

OBJECTIVE Through the study on different doses of puerarin on blood coagulation time,platelet aggregation and the role of hemorheology to investigate the effect of puerarin on coagulation function and its mechanism of action.METHODSThree different doses of oral liquid of puerarin were given respectively in normal mice,the clotting time and bleeding time were measured;after dose conversion the three different doses of oral liquid of puerarin were given in normal rats for the study on the index of platelet aggregation hemorheology.RESULTS Different doses of puerarin group could significantly prolong the coagulation time;significantly inhibited platelet aggregation and reduce the high,medium and low shear rate whole blood viscosity.CONCLUSION These results suggest that puerarin has potent anti-coagulant.The anti-coagulant effect is related to inhibitory effect on platelet aggregation and improve hemorheology.