An Analysis on Changes of Rheopneumography Assessing the Therapeutic Effects of Drug Xinin on Silicosis

Objective To explore the therapeutic effects of Drug Xinin on silicosis.Methods Using the double blind methods,silicosis patients were divided into therapeutic group,continuing therapeutic group and placebo control group respectively.For the therapeutic group,Xinin was administrated with a dosage of 300 mg per day in 6 days a week and lasted for 4 treatment periods(one treatment period was consisted of 3 months,and there was a break of 1 month between two treatment periods).For the continuing therapeutic group,Xinin was administrated with the same dosage as the therapeutic group for the first 4 treatment periods, and a dosage of 450mg per day in 5th and 6th treatment periods.The therapeutic effects were assessed by rheopneumography;then the difference of therapeutic effects among these three groups were evaluated by analysis of variance of randomized block design and profile analysis.Results It was found that all of the index values of rheopneumography,such as Zk,Ha/Hs,Q-B,Q-B/B-Y and Q-BI,had an ascent tendency with time going on(P0.05).Though the differences were not significant in statistics(P0.05),the therapeutic effects of therapeutic group were better than those of placebo control group.Conclusion The rheopneumography can be used to reflect the changes of lung blood flow dynamics of silicosis patients.The Hd/Hs index can be used as a delicate,simple and woundless index in initial clinical observation on therapeutic effects of silicosis.