The prevention of nausea and vomiting after laparoscopic cholecystectomy with dexamethasone combined with droperidol during induction of general anesthesia

Objective:To explore the effect of prevention for postoperative nausea and vomiting after laparoscopic chyolecystectomy with dexamethasone combined with droperidol during induction of general anesthesia.Methods:Two hundred and forty patients with ASA Ⅰ-Ⅱ who would undergo laparoscopic cholecystectomy were randomly divided into three groups(80 patients in each group).Group Ⅰ(control group)was not given dexamethasone and droperidol in induction of general anesthesia.Group Ⅱ was given only 10 mg dexamethasone.Group Ⅲ was given 10 mg dexamethasone and 40 ug/kg droperidol.All patients were observed within postoperative 48 hours for nausea and vomiting.Results:The incidence of nausea and vomiting in group Ⅰ,Ⅱ and Ⅲ was respectively 72.5%,32.5% and 7.5%,which had significant differences among groups(P0.05).Conclusions:The nausea and vomiting after laparoscopic cholecystectomy can be prevented maximally with dexamethasone combined with droperidol in small dose during induction of general anesthesia.