The changes of serum levels of CA19-9 before and after gamma knife-therapy in pancreatic carcinoma patients and its clinical significance

Objective To evaluate the effect of radiotherapy in the pancreatic carcinoma patients and their prognosis through detecting the changes of serum CA19-9 levels before and after gamma-knife stereotactic radiotherapy.Methods The serum CA19-9 levels in 40 pancreatic carcinoma patients before and after radiotherapy by means of elecctrochemiluminescence.Results There was significant difference(P0.05) in the serum CA19-9 levels between before and after radiotherapy(128.06±82.46 U/ml vs 52.72±55.62 U/ml);After radiotherapy,the level of CA19-9 was significantly lower in patients who were complete remission and partial remission than in those who were stable and even progressive(P0.05,35.43±18.22 U/ml vs 71.55±63.28 U/ml).Conclusion Serum CA19-9 can be an important objective indicator for the diagnosis,therapeutic effects observation and prognosis of pancreatic carcinoma,stereotactic radiotherapy can lower the level of serum CA19-9 in pancreatic carcinoma patients.