Efficacy Analysis of Three-dimensional Conformal Radiotherapy with Increasing Dose in Late Course in 81 Cases of Pancreatic Cancer Patients

Objective To observe the clinical efficacy of three-dimensional conformal radiotherapy with increasing dose in late course for patients with stage Ⅱ,Ⅲ pancreatic cancer.Methods A total of 81 cases of stage Ⅱ or Ⅲ pancreatic cancer patients treated with three-dimensional conformal radiotherapy with increasing dose in late course were recruited for the study.Remission rate of pancreatic cancer patients with pain,serum CA19-9 level change and survival rate were observed.Results After the treatment,remission rate of pancreatic cancer patients with pain was 76.2%;average serum CA19-9 level significantly dropped from 383.6 ± 126.7 U/mL before treatment to 83.5 ± 46.1 U/mL after treatment(P 0.001).1-,2-,3-and 5-year survival rate of pancreatic cancer patients after radiotherapy were 71.6%,28.4%,19.8%,and 3.7%,respectively.Univariate analysis showed that SUV value before treatment,clinical stage,radiation dose and over two cycles(including 2 cycles) chemotherapy were prognostic factors for pancreatic cancer patients with radiotherapy;multivariate analysis found that the SUV value before treatment and radiotherapy dose was an independent prognostic factor.Approximately 56.8% of the patients hadⅠ,Ⅱ level gastrointestinal reactions during the radiotherapy,and gastrointestinal ulcers were observed in approximately 11.1% of the cases after radiotherapy.Conclusion Three-dimensional conformal radiotherapy with increasing dose in late course can significantly improve the life quality and the survival rate in locally advanced pancreatic cancer patients,which could be a major treatment for stage Ⅱ,Ⅲ pancreatic cancer patients.