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2002•Chinese Journal of Hospital PharmacyRequires access

Studies on effect of azone on percutaneous absorption of sinomenine gel in vitro

Zhang Bing

Open publisher page 1 citations

Abstract

OBJECTIVE To investigate the effect of different content of azone on percutaneous absorption of sinomenine gels in vitro, and to decide an amount of azone for the gel. METHODS The transdermal penetration in Franz diffusion apparatus with excised mice skin of sinomenine gels with different content of azone was studied. The content of sinomenine was determined by HPLC. RESULTS The percutaneous absorption of sinomenine gel containing 2% azone was the best. The permeation process of sinomenine gel in vitro could be described by Higuchi's Equation. CONCLUSIONS 2% azone is selected as the enhancer of sinomenine gel.

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What this paper is about

OBJECTIVE To investigate the effect of different content of azone on percutaneous absorption of sinomenine gels in vitro, and to decide an amount of azone for the gel. METHODS The transdermal penetration in Franz diffusion apparatus with excised mice skin of sinomenine gels with different content of azone was studied. The content of sinomenine was determined by HPLC. RESULTS The percutaneous absorption of sinomenine gel containing 2% azone was the best. The permeation process of sinomenine gel in vitro could be described by Higuchi's Equation. CONCLUSIONS 2% azone is selected as the enhancer of sinomenine gel.

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Available abstract

OBJECTIVE To investigate the effect of different content of azone on percutaneous absorption of sinomenine gels in vitro, and to decide an amount of azone for the gel. METHODS The transdermal penetration in Franz diffusion apparatus with excised mice skin of sinomenine gels with different content of azone was studied. The content of sinomenine was determined by HPLC. RESULTS The percutaneous absorption of sinomenine gel containing 2% azone was the best. The permeation process of sinomenine gel in vitro could be described by Higuchi's Equation. CONCLUSIONS 2% azone is selected as the enhancer of sinomenine gel.

Key concepts: Azone, Sinomenine, Chemistry, Chromatography, Permeation, In vitro, Absorption (acoustics), Penetration (warfare)

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