2004•ZhongcaoyaoRequires access

Penetration of transdermal enhancers on percutaneous permeation of Sinomenine Gels in vitro

Wu Feng

Abstract

Object To observe the effects of several transdermal enhancers on the permeation of sinomenine in Sinomenine Gels (SG). Methods The transdermal penetration in Franz diffusion cell for isolated rat skin of SG by different content enhancers with Azone, mentha camphor, and oleic acid, respetively was studied. The content of sinomenine was determined by HPLC. Results The above- mentioned transdermal enhancers showed the significant effect on sinomenine in SG in vitro with the density sequence as Azonementha camphoroleic acid, and 2% Azone plus 10% oleic acid had the strongest effect in all. Conclusion 2% Azone plus 10% oleic acid as the enhancer of SG is the best.

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Key concepts: Azone, Transdermal, Sinomenine, Oleic acid, Permeation, Chemistry, Chromatography, Penetration (warfare)