Clinical analysis of mifepristone in treatment of patients with perimenopause dysfunctional uterine bleeding

Objective: To study the therapeutical effect of lowdose mifepristone on peripheral menopause syndrome. Methods: 24 cases with perimenopausal dysfunctional uterine bleeding were selected from patients treated in center for Women and Children's Health in Bayuquan district,Yingkou City from March 2007 to December 2008. Mifepristone tablets were taken 12.5 g every night for 3 months.Then observed the therapeutic effect. Results: B -ultrasonic examination showed that before treatment endometrial thickness of 24 patients was 1.1-2.1 cm,within 1 month treatment 0.6-1.0 cm, within 2 months treatment was 0.3-0.7 cm.After 3 months treatment,they had thin endometrium. Statistically significant difference could be found between before and after treatment endometrial thickness ( P 0.05). During treatment 24 patients were amenorrhea. Menstruation would be abnormal for 3-6 weeks after treatment. Conclusion: Treatmentment of perimenopausal dysfunctional uterine bleeding with low-dose mifepristone is a safe and effective method.