Evaluation of the effects of detection of serum thyroid peroxidase antibody and thyroid globulin antibody in Graves patients with hyperthyroidism treated with ~(131)I

OBJECTIVE To explore the effect of detected TPOAb and TGAb in evaluating the effect of 131I treatment of Graves disease(GD),to provide the reference for the clinical treatment.METHODS By using electrochemical chemiluminescence immunoassay method,the level of TGAb and TPOAb was determined in147 cases of GD patients,and according to the results of detection they were divided into positive group and negative group.Analysis of difference in TPOAb,TGAb levels was made between the GD patients and normal persons before and after 131I treatment;the dynamic change of serum TPOAb,TGAb level with relation to hypothyroidism was observed.RESULTS In Graves patients the levels of serum TPOAb,TGAb were significantly higher than those in the control group(t=6.326,4.260,P0.05);serum TPOAb,TGAb levels of GD patients were significantly lower after treatment than before(t=2.043,2.075,P0.05).3 months,18 months after treatment,the positive rate of serum TPOAb was obviously decreased(P0.05);6 months after treatment the positive rate of serum TGAb was the highest,there was significant difference compared with before treatment(P0.05),after 18 months the positive rate of serum TGAb descended to the lowest,compared with before treatment(P0.05).CONCLUSION 131I is the main treatment for GD,its therapeutic effect may be associated with the down-regulation of serum TPOAb,TGAb levels,the detection of serum TPOAb,TGAb level can be taken as one of the indicators to evaluate the clinical effect.