Clinical values of serum TGAb and TPOAb detection in the diagnosis of autoimmune thyroid diseases

Objective To evaluate the diagnosis value of serum thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)in autoimmune thyroid diseases(AITDs).Methods Electrochemiluminescence assay was performed to detect serum TGAb and TPOAb in 120patients with Graves′disease(GD,GD group),130patients with Hashimoto′s thyroiditis(HT,HT group),and 90healthy subjects(control group).Results The absolute concentrations and positive rates of serum TGAb and TPOAb were significantly different among the three groups(P 0.05),with the highest values observed in HT group.The areas under receiver operating characteristic curve of TGAb and TPOAb were 0.866and 0.990in the diagnosis of GD,were 0.960and 0.991in the diagnosis of HD,and comparison between GD and HT groups indicated that the Youden indexes of the serum TGAb and TPOAb were 0.333and 0.549,respectively.Conclusion Detection of serum levels of TGAb and TPOAb could be used for the diagnosis of GD and HT,and the diagnostic value of TPOAb might be superior to TGAb,but the value of differential diagnosis of GD and HT might be relatively low.