Importance of 24-hour smoothly anti-hypertension to protect target organ in essential hypertensive patients

Objective: To access the importance of 24-hour smoothly anti-hypertension to protect target organ in essential hypertensive patients. Method: Twenty-two normal controls and 114 EH patients admitted in our hospital were taken ABPM, then according to the degree of target organ damage and the LVMI, these patients were divided into 3 clinical stage and two groups with or without LVH.Result:there were positive correlations between the level of 24 h,daytime and nighttime mean SBP, SBP load and its variability and LVMI (P 0.01), but the relationship between the nighttime SBP variability and LVMI was the strongest (r=0.45,P 0.01); the incidence of TOD in the patients with lower 24-hour SBP load (25%) were less than that in which with higher 24-hour SBP load (≥25%)(27.3% vs 71.4%, P 0.01), and the incidence in the patients with lower SBP variability (11.9) also significantly decreased than that in which with higher SBP variability (≥11.9) (28.1% vs 88.0%, P 0.01).Conclusion: the higher levels of 24 h SBP load and its variability also were risk factors of left ventricular hypertrophy; it was helpful for us to protect target organ better that we also decreased the 24h SBP load and its variability, especially nighttime, in order to 24-hour smoothly control the blood pressure.