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2006•Central Plains Medical JournalRequires access

The expression and significance of HSP70 and HSP27 in cervical squamous cell carcinoma

Jianqiang Mi

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Abstract

Objective To explore the expressions of HSP70 and HSP27 in cervical squamous cell carcinoma and their correlation.Methods Immunohistochemical method for HSP70 and HSP27 were performed on 60 cases of cervical squamous carcinomas,18 cases of cervical intraepi the lial neoplasia(CIN) and 10 cases of normal cervical tissues.Results In cervical squamous cell carcinoma,the expression of HSP70 and HSP27 were significantly higher than that of normal cervical tissues;the expression of HSP70 was significantly correlated with the pathological grade,clinical stages and lymph node metastasis,the expression of HSP27 was significantly correlated with the pathological grade;the expression of HSP70 was not correlated with HSP27.Conclusion HSP70 and HSP27 should play an important role in the genesis and development of cervical squamous cell carcinoma;HSP70 can be the important target in predicting the prognosis of cervical squamous cell carcinoma.

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What this paper is about

Objective To explore the expressions of HSP70 and HSP27 in cervical squamous cell carcinoma and their correlation.Methods Immunohistochemical method for HSP70 and HSP27 were performed on 60 cases of cervical squamous carcinomas,18 cases of cervical intraepi the lial neoplasia(CIN) and 10 cases of normal cervical tissues.Results In cervical squamous cell carcinoma,the expression of HSP70 and HSP27 were significantly higher than that of normal cervical tissues;the expression of HSP70 was significantly correlated with the pathological grade,clinical stages and lymph node metastasis,the expression of HSP27 was significantly correlated with the pathological grade;the expression of HSP70 was not correlated with HSP27.Conclusion HSP70 and HSP27 should play an important role in the genesis and development of cervical squamous cell carcinoma;HSP70 can be the important target in predicting the prognosis of cervical squamous cell carcinoma.

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Available abstract

Objective To explore the expressions of HSP70 and HSP27 in cervical squamous cell carcinoma and their correlation.Methods Immunohistochemical method for HSP70 and HSP27 were performed on 60 cases of cervical squamous carcinomas,18 cases of cervical intraepi the lial neoplasia(CIN) and 10 cases of normal cervical tissues.Results In cervical squamous cell carcinoma,the expression of HSP70 and HSP27 were significantly higher than that of normal cervical tissues;the expression of HSP70 was significantly correlated with the pathological grade,clinical stages and lymph node metastasis,the expression of HSP27 was significantly correlated with the pathological grade;the expression of HSP70 was not correlated with HSP27.Conclusion HSP70 and HSP27 should play an important role in the genesis and development of cervical squamous cell carcinoma;HSP70 can be the important target in predicting the prognosis of cervical squamous cell carcinoma.

Key concepts: Hsp27, Hsp70, Immunohistochemistry, Pathological, Medicine, Lymph node metastasis, Cervical cancer, Pathology

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