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2007•Chinese Journal of Hospital PharmacyRequires access

Determination of paeoniflorin in Yangxue Qingnao granules by LC-MS

Baoyu Cai

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Abstract

OBJECTIVE To establish a method for determining the content of paeoniflorin in Yangxue Qingnao granules by LC/MS.METHODSSample was extracted by 50% mathanol-water solution,separated by SunfireTMC18 column(2.1 mm×150 mm,5 μm),mobile phase was mathanol-0.2% formic acid in gradient change.Mass spectrometry was set in electrospray(ESI+) molde,and SIR function for quantification.RESULTSThe linear range of paeoniflorin was 0.68-13.52 mg·L-1.The recovery rate was 96.0% with an RSD of 1.54%(n=6).CONCLUSIONThc method is simple,rapid,accurate and sensitive,can be used to determine the content of paeoniflorin in Chinese traditional medicine.

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OBJECTIVE To establish a method for determining the content of paeoniflorin in Yangxue Qingnao granules by LC/MS.METHODSSample was extracted by 50% mathanol-water solution,separated by SunfireTMC18 column(2.1 mm×150 mm,5 μm),mobile phase was mathanol-0.2% formic acid in gradient change.Mass spectrometry was set in electrospray(ESI+) molde,and SIR function for quantification.RESULTSThe linear range of paeoniflorin was 0.68-13.52 mg·L-1.The recovery rate was 96.0% with an RSD of 1.54%(n=6).CONCLUSIONThc method is simple,rapid,accurate and sensitive,can be used to determine the content of paeoniflorin in Chinese traditional medicine.

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Available abstract

OBJECTIVE To establish a method for determining the content of paeoniflorin in Yangxue Qingnao granules by LC/MS.METHODSSample was extracted by 50% mathanol-water solution,separated by SunfireTMC18 column(2.1 mm×150 mm,5 μm),mobile phase was mathanol-0.2% formic acid in gradient change.Mass spectrometry was set in electrospray(ESI+) molde,and SIR function for quantification.RESULTSThe linear range of paeoniflorin was 0.68-13.52 mg·L-1.The recovery rate was 96.0% with an RSD of 1.54%(n=6).CONCLUSIONThc method is simple,rapid,accurate and sensitive,can be used to determine the content of paeoniflorin in Chinese traditional medicine.

Key concepts: Paeoniflorin, Formic acid, Chromatography, Chemistry, High-performance liquid chromatography

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