Effect of resveratrol on inhibiting SGC-7901 tumor cell proliferation

Aim To study effect of resveratrol (Res) on inhibiting SGC-7901 cell proliferatrion.Methods MTT method was used to test the inhibition rates of Res in SGC-7901 tumor cells;FCM was used to detect the influence of Res on tumor cell apoptosis and cell cycle;fluorescence microscope was used to identify the tumor cell apoptosis in the morphology.Results Res inhibited SGC-7901 cell proliferatrion in a dose-dependent manner. Its IC50was 164.69 μmol·L-1.When the concentration of Res was 44,88 and 176 μmol·L-1,the rates of proliferatrion were 29.693%,33.986% and 85.634%.G1 term is gradually diminished,and S term gradually increased.G2/M term gradually reduced.According to the morphology,the apoptosis body increased,tumor cell's caryoplasm reduced and tumor cell karyopyknosis,the extent of the colour deepened with the concentration of the Res.Conclusion Res can inhibit tumor cell proliferation and induce tumor cell apoptosis.