IL-18 and MMP-9 detection and clinical significance in patients with acute coronary syndrome

Objective To discuss the relationship between interleukin-18(IL-18) or matrix metalloproteinase-9(MMP-9) and acute coronary syndrome(ACS),and find a new way for the diagnosis and treatment of ACS.Methods A total of 79 inpatients were divided into control group,unstable angina pectoris(UAP) group and acute myocardial infarction(AMI) group according to clinical symptom and the result of coronary arteriography.Femoral artery serum IL-18 and MMP-9 were measured with ELISA.Results The level of serum IL-18 was significantly lower in control group than UAP group(P 0.01),and the level in UAP group was lower than that in AMI group(P 0.01).On the other hand,the level of serum MMP-9 was significantly lower in control group than UAP group(P 0.01),and the level in UAP group was lower than that in AMI group(P 0.01).Conclusion IL-18 and MMP-9 are expressed in healthy subjects,and highly expressed in patients with ACS.It can be used as an important prognostic marker and treatment target for ACS.