Effects of Different Dose of Folic Acid on the Plasma Homocysteine in Patients with Cerebral Infarction

Objective: To observe the effects of different dose(5 mg/d)of folic acid on the plasma homocysteine in patients with cerebral infarction.Method: 120 patients with cerebral infarction and hyperhomocysteinemia were randomly divided into 3 groups,40 cases in each group.A group was taken folic acid 5 mg/d,;B group was taken by the treatments of folic acid 10 mg/d;C group was taken by the treatments of folic acid 20 mg/d;The plasma homocysteine(Hcy)concentration was detected before and after 4 weeks treatment.Result: After 4 weeks treatment,the level of plasma Hcy significantly decreased in 3 groups(all P0.001) than the level of prior treatment.But there was no difference between 3 groups after the treatment(all P0.05).Conclusion: The plasma homocysteine in patients with cerebral infarction was decreased after the treatment of folic acid.The degree of the homocysteine decreased has no relationship with the doses(5 mg/d) of the medicine.