Observing the Effect of Montelukast on 73 Children with CVA

Objective: To study curative effect of Montelukast in patient with CVA(cough variant asthma).Method: 73 patients with CVA were assigned to two groups in the ratio of 2:1.The study group has 49 cases and the others belonging to the control group.The control group were treated with Bambuterol Hydrochloride and Loratadine.The treatment withdraw until the symptom disappeared,the recurrence rate of CVA and incidence of CVA-Asthma conversion were investigated at the follow-up of 12 months.The study group was treated with Montelukast besides Bambuterol Hydrochloride and Loratadine.Bambuterol Hydrochloride and Loratadine were with drawn until the symptom disappeared,however,Montelukast was still taken till the course of treatment reached 12 weeks.The incidence of CVA recurrence rate and CVA-Asthma conversion were also investigated at the follow-up of 12 months.For 32 patient who were older than 6 years,the FEV1 and PEF were measured before treatment and 12 weeks after treatmen.Result: The remission time of study group was shorter than the control group;the recurrence rate and incidence of CVA-Asthma convension are lower.Lung function in study group improved significantly compared to the control group after 12 weeks-treatment(P0.01. Conclusion :The curative effect of Montelukast in patients with CVA was significant,with little side effect and good obedience.