Initial evaluation of the ACL-Futura coagulation analyzer

Objective: To evaluate the technical performance of the ACL-Futura coagulation analyzer.And to provide data for various laboratories in the selection of coagulation analyzer.Methods: To co-evaluated the following assay:Prothrombin time(PT),Activated partial thromboplaslin time(APTT),Fibrinogen-C(Fbg-C,Clauss method),Fibrinogen-D(Fbg-D,Derived method) and Glycated Hemoglobin A1c(GHbA1c,Lactic-gel agglomerate method).The precision,stability,accuracy,linearity and interferences were assessed.Results:The analyzer shows an within-between day imprecision with normal control plasma,for PT of 1.0 to 1.3%,APTT of 1.8 to 3.8%,Fibrinogen-C of 2.4 to 3.3%,Fibrinogen-D of 1.4 to 1.5% and GHbA1c of 4.4 to 7.6% respectively.The calibration curves were linear within the concentration range of 1.75-5.31mg/L for Fbg-C,0.67-2.67mg/L for Fbg-D and 1.44-14.4 for GHbA1c(r0.998,P0.01).In addition,the correlation between the dilution of sample and the result(second) of APTT and PT is good(n=6,r0.999,P0.01).Experimental results also show that relative deviations of ATTT,PT,Fbg-C and Fbg-D were 3.9%,0.6%.0.6% and 0.4% respectively.It is not significantly affected by such biological products as haemoglobin,bilirubin and triglycerides up to 4.0g/L,127.3μmol/L and 6.36mmol/L respectively.Conclusion: Instrument is reliable,precision,easy to use and capable of fast sample throughput.