Effects of Flunarizine on learning and memory in mice after cerebral ischemia-reperfusion injury

[Objective] To investigate the effects of Flunarizine on learning and memory in mice or rats after cerebral ischemia-reperfusion damages. [Methods] The models of clamping the bilateral common carotid arteries (CCA) and ischemia followed by reperfusion were used, Kun-Ming mice and Wistar rats were randomly divided into 3 groups and administered. After the usual rear for 1 week, step down, Y-Labyrinth tests were used to measure the changes of the ability to learn and memory in mice and rats, respectively. [Results] The error number of mice in step-down test and shock number of learning or memory,escaple time in Y-labyrinth of rats were decreased. Step-down latencies were increased. [Conclusion] Results showed that cerebral ischemia-reperfusion damage could result in dysmnesia, Flunarizine could improve the memory retention after ischemia.