Effects of Cyproheptadine on Learning and Memory in Mice after Cerebral Ischemia-reperfusion Injury

Objective to observe the effect of Cyproheptadine on learning and memory in mice after cerebral ischmia-reperfusion damage.Methods We adopted the mode that clamping the bilateral common cartid arteries(CCA) and ischmia for 15 min followed by reperfusion.Kun-Ming mice were randomly divided into three groups,cyp group,nimodipine group and control group,the cyp group was injected with cyp 2 mg·kg -1 ·d -1 ,nimodipine group with nimodipine 2 mg·kg -1 ·d -1 ,control group with 0.9% NS 10 ml·kg -1 ·d -1 ,after the usual rear for 1 week,the change of learning and memory were observed in open field,water-maze and one trial passive avoidance responded.Results There is marked difference between first test and second test after 24 h in cyp group,but the control group has no change by paired test.Couclusion The results show that cerebral ischemia-reperfusion damage could result in dysmnesia,cyp could impove the memory retention after ischemia.