Effects on Oxidative Stress and Microinflammation State of Simvastatin in Maintenance Hemodialysis Patients

Objective To explore the effects on oxidative stress and microinflammation state of Simvastatin in maintenance hemodialysis patients. Methods 80 patients with uraemia who underwent maintenance hemodialysis were divide into simple maintenance hemodialysis group(n=40)and Simvastatin group(n=40, and measured the serum concentrations of MDA, SOD,T-AOC, CRP,IL-6 and TNF-α, then these results was analyzed by statistical methods. Results The level of post-treatment serum MDA, CRP, IL-6 and TNF-α in the research group patients with Simvastatin were significant lower than the prior treatment and the control group(P0.01), and the level of serum SOD and T-AOC were significant higher than the prior treatment and the control group(P0.01). while the level of serum MDA, SOD,T-AOC, CRP,IL-6 and TNF-α in the control group between post-treatment and prior treatment have no statistical significance. Conclusion Simvastatin can alleviate oxidative stress and microinflammation state in maintenance hemodialysis patients, Furthermore, Simvastatin has fewer adverse reactions and a wide area of potential clinical applications.