Inhibitory Effects of Simvastatin on Oxidative Stress of Patients with Type 2 Diabetes Mellitus

To study the effects of simvastatin on oxidative stress and blood lipid metabolism of patients with type 2 diabetes mellitus,168 diabetic patients were randomly divided into simvastatin group and placebo group.The serum levels of SOD and MDA,as well as the lipid profile in patients were observed before and after 12 weeks treatment,respectively.The results showed that the serum levels of SOD in diabetic patients before treatment were significantly lower,and whereas level of MDA was higher than that of controls(P0.05).The serum levels of SOD in patients after 12 weeks consecutive simvastatin treatment were significantly higher,and whereas the serum level of MDA was significantly lower than that of before the treatment(P0.05).There was no significant difference on the serum levels of SOD and MDA observed before and after treatment in the placebo group(P0.05).The serum levels of HDL-C in patients after treatment with simvastatin were higher,and while the serum levels of TG,TC,LDL-C and VLDL-C were significantly lower than that of before the treatment(P0.01).There was no significant difference on the profiles of lipids before and after treatment in the placebo group(P0.05).Therefore,the simvastatin could significantly inhibit oxidative stress provoked by hyperglycemia and had beneficial effects on the lipid homeostasis of diabetic patients.