2005•Zhongguo yaofangRequires access

Determination of Principal Components in Levofloxacin Hydrochloride Ointment by HPLC

Zhu Meirong

Abstract

OBJECTIVE:To establish a HPLC method for the determination of levofloxacin hydrochloride in the levoflo_ xacin hydrochloride ointment.METHODS:The chromatographic column was C 18 ,the mobile phase was consisted of0.05mol/L citric acid-acetonitrile(85∶15)with detection wavelength at293nm and flow speed at1.0ml/min,the column temperature was40℃and the sample size was10μl.RESULTS:Good linear relation was achieved when the levofloxacin hydrochloride concen-tration was at the range of3.88～37.88ug/ml(r=0.9998);The average recovery was99.4%(n=9).CONCLUSION:This determination method is accurate,reliable and it can act as an effective quality control for levofloxacin hydrochloride ointment.

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Key concepts: Chromatography, Levofloxacin, High-performance liquid chromatography, Chemistry, Hydrochloride, Organic chemistry, Antibiotics, Biochemistry