Effects of Changyuning on Plasma D-dimer level and Platelet Count in Patients with Active Ulcerative Colitis

Objective:To observe the impact of Changyuning on the plasma level of D-dimer(D-D) and platelet(PLT) count in patients with active ulcerative colitis(AUC).Methods:The treatment group had 50 patients with AUC,and were treated with Changyuning.Before and after treatment,the plasma level of D-D and PLT count in the treatment group were observed and then were compared to those in 20 healthy control subjects.Results:The plasma D-D level and PLT count of active UC patients were higher than the healthy controls before treatment,and the difference was statistically significant(P 0.05).After treatment,plasma D-D level and PLT count of active UC patients were decreased(P 0.05 compared with those before treatment),and the differences between healthy control group and treatment group were insignificant(P 0.05).Conclusion:Changyuning has certain therapeutic effect for AUC,and adjusting the level of D-D and inhibition of platelet activation may play important roles in the therapeutic mechanism of Changyuning.