The changes of platelet count in active ulcerative colitis and its clinical significance

Aim To evaluate the changes of platelet count in patients with active ulcerative colitis(UC) and its clinical significance.To investigate whether UC patients were in hypercoagulabale statet or not and whether platelet count could be used to evaluate ulcerative colitis activity.Methods 51 active UC patients and 20 healthy controls were admitted.The values of PLT,PT and FIB of the patients and healthy control were all analyzed.In addition,the relationship between PLT and inflammatory markers(ESR and CRP) of UC patients were investigated.Results The PLT count and FIB values in all active UC patients were significantly higher than the healthy control(P0.05).However,PT values were no significant difference between the two groups.In the UC group,PLT count were remarkable different depending on the activity of UC(P0.01),and have a positive relationship between ESR and CRP values(R= 0.589;0.413,respectively).Conclusion UC patients were in hypercoagulable state,PLT counts have a positive relationship between ESR and CRP values and could be used to evaluate UC activity.