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2012•Journal of Jilin Institute of Chemical TechnologyRequires access

Study on Process Optimization for Preparation of Asprin β-cyclodextrin Inclusion Compound

Fangli Zhong

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Abstract

Objective: The aim was to optimize the process of preparing the inclusion compound of asprin-β-cyclodextrin.Method:The ratio of aspirin and β-cyclodextrin,inclusion temperature,stiring time was selected as the criterion of the orthogonal design.With the inclusion rate as the main evaluation index,the inclusion process was optimized through orthogonal test(L9(34)).Result:The optimum inclusion process was as follows:the ratio of aspirin and β-cyclodextrin was 12,inclusion temperature was 60 ℃,stiring time was 1.5 h.Conclusion:The process that asprin was included with β-cyclodextrin was stable,feasible and effective.

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What this paper is about

Objective: The aim was to optimize the process of preparing the inclusion compound of asprin-β-cyclodextrin.Method:The ratio of aspirin and β-cyclodextrin,inclusion temperature,stiring time was selected as the criterion of the orthogonal design.With the inclusion rate as the main evaluation index,the inclusion process was optimized through orthogonal test(L9(34)).Result:The optimum inclusion process was as follows:the ratio of aspirin and β-cyclodextrin was 12,inclusion temperature was 60 ℃,stiring time was 1.5 h.Conclusion:The process that asprin was included with β-cyclodextrin was stable,feasible and effective.

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Available abstract

Objective: The aim was to optimize the process of preparing the inclusion compound of asprin-β-cyclodextrin.Method:The ratio of aspirin and β-cyclodextrin,inclusion temperature,stiring time was selected as the criterion of the orthogonal design.With the inclusion rate as the main evaluation index,the inclusion process was optimized through orthogonal test(L9(34)).Result:The optimum inclusion process was as follows:the ratio of aspirin and β-cyclodextrin was 12,inclusion temperature was 60 ℃,stiring time was 1.5 h.Conclusion:The process that asprin was included with β-cyclodextrin was stable,feasible and effective.

Key concepts: Cyclodextrin, Inclusion compound, Inclusion (mineral), Process (computing), Chemistry, Chromatography, Process engineering, Materials science

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