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2011•Chinese Journal of Hospital PharmacyRequires access

Preparation and in vitro release of ketoprofen sustained-release pellet tablets

Yan P. Yang

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Abstract

OBJECTIVE To prepare detoprofen sustained-release tablets.METHODS Extrusion-spheronization technique was introduced to prepare ketoprofen pellets and EudragitRS 30D and EudragitRL 30D were used as coating materials.Even mix the coated pellets with ketoprofen to prepare ketoprofen sustained-release tablets.RESULTS The data obtained proved that the formulation was useful for a sustained-release of ketoprofen,due to the percentage released in two hours was 30% and in the later ten hours was 70%.CONCLUSION The preparation technology is reliable and easy to operate.

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What this paper is about

OBJECTIVE To prepare detoprofen sustained-release tablets.METHODS Extrusion-spheronization technique was introduced to prepare ketoprofen pellets and EudragitRS 30D and EudragitRL 30D were used as coating materials.Even mix the coated pellets with ketoprofen to prepare ketoprofen sustained-release tablets.RESULTS The data obtained proved that the formulation was useful for a sustained-release of ketoprofen,due to the percentage released in two hours was 30% and in the later ten hours was 70%.CONCLUSION The preparation technology is reliable and easy to operate.

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Available abstract

OBJECTIVE To prepare detoprofen sustained-release tablets.METHODS Extrusion-spheronization technique was introduced to prepare ketoprofen pellets and EudragitRS 30D and EudragitRL 30D were used as coating materials.Even mix the coated pellets with ketoprofen to prepare ketoprofen sustained-release tablets.RESULTS The data obtained proved that the formulation was useful for a sustained-release of ketoprofen,due to the percentage released in two hours was 30% and in the later ten hours was 70%.CONCLUSION The preparation technology is reliable and easy to operate.

Key concepts: Ketoprofen, Pellets, Pellet, Chromatography, Chemistry, Extrusion, Materials science, Composite material

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