Efficacy of rosuvastatin on neurofunctional and blood lipid in patients with arteriosclerotic cerebral infarction

Objective: To explore the effect of rosuvastatin on the blood lipid and neurofunctional of patients with arteriosclerotic cerebral infarction. Methods: Sixty-two patients with cerebral infarction were divided into observation group and control group by a prospective randomized open method. Conventional therapy such as anticoagulants,dehydrating agent and drugs to improve the microcirculation was applied to all the patients; and the patients in the observation group were administered statin rosuvastatin calcium tablets in addition to the routine therapy. The blood lipid,nerve function,carotid intima- media thickness( IMT) and the infarct size were compared between the two groups before treatment,3,6 and 12 months after treatment. Results: Compared with the control group,the TC,TG and LDL of the observation group decreased( P 0. 01),the HDL increased( P 0. 01),the IMT diminished( P 0. 01)and the nerve function improved significantly after 12 months of treatment( P 0. 01). Before treatment,the infarct area had no significant difference between the two groups( P 0. 05); after treatment,the infarct area in the two groups diminished significantly.After 12 months of therapy,3 cases of large area of infarct and 7 cases of small area of infarct in the observation group improved( 41. 2%),and 1 case of large area of infarct and 4 cases of mall area of infarct in the control group improved( 22. 2%). The difference in the infarct area was not statistically significant after treatment for 3 months,6 months or 12 months( P 0. 05). Conclusions:Rosuvastatin can significantly improve the cerebral blood lipid and nerve function,decrease the adverse reactions and improve the clinical outcome of patients with cerebral infarction.