Expression of integrin α3 and Ki-67 in esophageal squamous cell carcinoma and its relation to the recurrence and metastasis of tumor

Objective:To investigate the expression of integrin α3 and Ki-67 in esophageal carcinoma and its relation to the recurrence and metastasis of tumor.Methods:The expression of integrin α3 and Ki-67 of the cases that survived over 5 years without recurrence or metastasis(group A) and died of recurrence or metastasis within 1 year(group B) were detected by immunohistochemistry.Results:No expression or little expression of integrin α3 of normal esophageal mucosa were detected,but varying degrees of expression in esophageal carcinoma.All tissue expressed Ki-67,which were found at the basilar part of normal squamous epithelium with express strength less than 1+ and esophageal carcinoma tissue.The integrin α3 and Ki-67 expressions of group B were significantly higher that of the group A(P0.01).The expression of integrin α3 in ESCC had interrelation with the tumor length,T stage and lymph metastasis(P0.05 to P0.01).The expression of Ki-67 had interrelation with tumor differentiation and lymph metastasis(P0.05 and P0.01).Conclusions:The expression of integrin α3 in esophageal squmous cell carcinoma is a significant marker in predicting the recurrence or metastasis of tumor,which combined with Ki-67 may be of prognostic value to predict the recurrence or metastasis of esophageal carcinoma.