Expression and significance of S100A4 in esophageal squamous cell carcinoma tissues

Objective:To investigate the expression and significance of S100A4 in esophageal squamous cell carcinoma tissues,and explore the role of S100A4 in the infiltration and metastasis of esophageal carcinoma.Methods:Expression of S100A4 in esophageal squamous cell carcinoma was detected by immunohistochemistry SP method.The relation of the expression of S100A4 and sex,age,size of tumor,degree of infiltration,lymphnode metastasis,grade of pathology and clinical stages was analyzed by using SPSS 13.0.Results:The expression of S100A4 was up-regulated in esophageal squamous cell carcinoma tissues.Significant differences of the expression rates of S100A4 was found between esophageal carcinoma and adjacent noncancerous tissue groups(P0.05).The expression of S100A4 was closely related to clinic pathological characteristics of esophageal squamous cell carcinoma;lymphnode metastasis groups had higher S100A4 expressions than without lymphnode metastasis groups(P0.05).In TNM stage,the positive expression of S100A4 increased remarkably from I to Ⅱ,then to Ⅲ(P0.05).Expression rate of S100A4 had negative relationship with cell differentiation(P0.05) and positive relationship with degree of infiltration(P0.05) in esophageal carcinoma tissues.Statistical analysis showed that the expressions of S100A4 had no significant relation with gender,age,size of tumor.Conclusion:S100A4 may play important roles in esophageal squamous cell carcinoma invasion and metastasis.The expression of S100A4 had a close correlation with lymphnode metastasis,which could promote lymphatic metastasis of esophageal carcinoma,and may inaugurate a new approach to esophageal carcinoma targeted therapy.