Clinical Research of Three Kinds of Intensive Insulin Treatment in Primary Type 2 Diabetes

Objective To study the short-term efficacy and safety of three insulin treatment,such as Insulin Aspart 30 Injection(A group),Novolin R plus insulin glargine at bed time(B group) and Novolin R plus Novolin N at bedtime(C group),in the treatment primary type 2 diabetic patients.Methods hospitalized patients with type 2 diabetes were randomized to 3 kinds of intensive insulin therapy.To adjust the insulin doses according to blood glucose levels.To compare the overall level of blood glucose control,compliance time,and insulin doses,and the incidence of low blood sugar,et al.Results ①The blood glucose level can be achieved up to the standard in allgroups after treatment and the results were not significant difference among three groups(P0.05);②blood glucose standard time and the average total daily insulin dosage were no difference among three groups(P0.05);③ In the aspect of incidence of hypoglycemia.It is defined as low blood sugar when the peripheral blood glucose ≤3.9 mmol/L.A group occurred in 2 cases,the rate was 6.7%;B group had 2 cases,the rate was 6.7%;C group 3 cases,the rate was 10%.Low blood glucose often seen in the early morning 0:00 to 4:00.There was no hypoglycemia coma occurred.the incidence of hypoglycemia in 3 groups was not statistically difference(P0.05).Conclusion The short-term effect and safety of Three intensive insulin treatment in blood glucose control had no significant difference.But we need to pay more attention to night blood glucose monitoring.