Effects of Losartan on Insulin Sensitivity in Hyperglycemic Patients with Hypertension

Objective To investigate the effects of losartan on insulin sensitivity in hyperglycemic patients with hypertension.Methods One hundred ten hyperglycemic patients with hypertension were divided randomly into 2 groups,who were treated with amlodipine(HG/A group)and losartan(HG/L group),respectively,for 12 weeks.Patients with metabolic syndromes were treated with amlodipine(MS/A group),and with losartan(MS/L group).Body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),fasting plasma insulin(FINS),total cholesterol(TC)low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG)and homeostasis assessment model of insulin resistance(HOMA-IR)were evaluated before and following treatment.Results After 12 weeks of treatment,SBP and DBP were significantly reduced as compared with baseline in 2 groups(P0.01).FINS and HOMA-IR decreased more in HG/L group than in HG/A group(P0.01).FINS and HOMA-IR reduced more in MS/L group than in MS group(P0.01).Conclusion A 12-week losartan treatment brings about not only a significnat reduction of SBP and DBP but also an improvement of insulin sensitivity in patients with hyperglycosemia with hypertenstion.And insulin sensitivity can also be improved in MS patients.