Interleukin 10 in the pathogenesis of asthma

【Objective】 To study the role of interleukin 10 in the pathogenesis of bronchial asthma. 【Methods】Asthma group with ovalbumin OVA allergen preparation C57 mice model of asthma, antibody IL-10 intervention group and asthma group were 24 h, 48 h, 96 h after excitation, and 8D underwent bronchoalveolar lavage(BAL), enzyme linked immunosorbent assay(ELISA) in BALF by IL- 10, IL- 12, TNF- α and IgE in serum, the concentration of nitric oxide. 【Results】 IgE, the content of NO in serum TNF- α and BALF in asthma model group and intervention group was significantly higher than that of the control group. Asthma group and intervention group in both IL- 10 and IL- 12 positive correlation, a negative correlation between IL- 10 and TNF- α in asthmatic group, IgE. Concentration of IL- 10 antibody intervention group and IL- 10 concentration of TNF- α, IgE, NO in linear regression analysis, showed negative correlation. 【Conclusion】 IL- 10 may be is involved in the pathogenesis of bronchial asthma throughout the process, with reduced IL-10 content, bronchial asthma aggravated sexual. Therefore in bronchial asthma in different periods to detect IL- 10 levels has important clinical significance.