Relationship analysis between titer of IgG antibody in pregnant women with blood type O and hemolytic disease of newborn

Objective:To explore the relationship between the IgG blood group antibody titer in the pregnant women with blood type O and hemolytic disease of newborn.Method:IgG blood group antibody titer of 2000 pregnant woman with blood type O was detected by microcolumn gel technique.Direct antiglobin test,indirect antiglobulin test and elution test were performed in the newborns.Bilirubin and hemoglobin level of newborn infants were tested with routine methods.The relationship between the IgG blood group antibody titer of pregnant women with blood type O and hemolytic disease of newborn were studied.Result:Among 2000 pregnant women with blood type O,IgG anti-A(B) blood group antibody titers of 1204 pregnant women were≥64 (60.2%).The rate of hemolytic disease of newborn was increased with the higher IgG blood group antibody titer in serum of pregnant women.Conclusion:Detecting of the IgG blood group antibody of pregnant women would be helpful to diagnose hemolytic disease of newborn,and could be used to reduce the incidence of hemolytic disease of newborn.