Observation of curative effects of Amiodarone on patients with acute coronary syndrome(ACS) and chronic heart failure and ventricular arrythmia

Objective: To observe the efficacy and safety of Amiodarone in treatment of ventricular arrythmia on acute coronary syndrome(ACS) and chronic heart failure patients and ventricular arrythmia.Methods: On the basis of regular treatment,Amiodarone was used in 52 patients with ACS and chronic heart failure and ventricular arrythmia,intravenous loading does of 3-5 mg/kg of Amiodarone was given within 10-20 min,followed by 0.75-1.50.mg/min infusion.If ventricular arrythmia was uncontrolled,additional bolus of 150 mg could be repeated every other 30 min,and oral Amiodarone 0.2 mg,tid,observation treatment for five days.Results: In 52 patients,35 cases(67.3%) were significant effective,11 cases(21.2%) were effective,6 cases(11.5%) were invalid,the total effective rate was 88.5%.There were no significant changes in the P-R,QRS,QT intervals during iv Amiodarone therapy.Conclusion: Amiodarone can be used effectively and safely to control ventricular arrythmia on ACS with chronic heart failure patients.